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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Publication : Journal of the National Cancer Institute

Evidence for a multiclonal origin of multicentric advanced lesions of Kaposi sarcoma

Team: Oncogenic Virus Epidemiology and Pathophysiology
Member: Antoine Gessain
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of the National Cancer Institute - 10 Jul 2007

Duprez R, Lacoste V, Brière J, Couppié P, Frances C, Sainte-Marie D, Kassa-Kelembho E, Lando MJ, Essame Oyono JL, Nkegoum B, Hbid O, Mahé A, Lebbé C, Tortevoye P, Huerre M, Gessain A

Link to Pubmed [PMID] – 17623796

J. Natl. Cancer Inst. 2007 Jul;99(14):1086-94

Kaposi sarcoma (KS) is a complex tumor of uncertain clonality. Studying the viral clonality of the human herpesvirus 8 (HHV-8) in KS to determine clonality of the tumors, a strategy that has been used previously with Epstein-Barr virus and its associated tumors, may elucidate whether multicentric (disseminated) KS lesions correspond to metastatic lesions or to expansions of independent clones.