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The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy

Caring for patients with rabies in developing countries – the neglected importance of palliative care

© Christine Schmitt, Meriem El Ghachi, Jean-Marc Panaud

Bactérie Helicobacter pylori en microscopie électronique à balayage. Agent causal de pathologies de l'estomac : elle est responsable des gastrites chroniques, d'ulcères gastriques et duodénaux et elle joue un rôle important dans la genèse des cancers gastriques (adénocarcinomes et lymphomes).

Publication : Oncoimmunology

Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota

Team: Biology and Genetics of Bacterial Cell Wall

Member: Ivo Gomperts Boneca

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Oncoimmunology - 18 Feb 2016

Pitt JM, Vétizou M, Gomperts Boneca I, Lepage P, Chamaillard M, Zitvogel L

Link to Pubmed [PMID] – 28197360

Oncoimmunology 2017;6(1):e1132137

Although anticancer therapy with immune checkpoint blockers has seen unprecedented success, it fails to control neoplasia in most patients and often causes immune-related adverse events (irAEs). Our recent research shows the immunostimulatory and antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species of the gut microbiota, signifying novel approaches to improve such immunotherapies.

Published on: 18 Feb 2016