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© Valérie Zeitoun
Stéthoscope. Centre Médical de l'Institut Pasteur (CMIP).
Publication : Dermatology (Basel, Switzerland)

Efficacy of rifampin-moxifloxacin-metronidazole combination therapy in hidradenitis suppurativa

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Dermatology (Basel, Switzerland) - 25 Nov 2010

Join-Lambert O, Coignard H, Jais JP, Guet-Revillet H, Poirée S, Fraitag S, Jullien V, Ribadeau-Dumas F, Thèze J, Le Guern AS, Behillil S, Leflèche A, Berche P, Consigny PH, Lortholary O, Nassif X, Nassif A

Link to Pubmed [PMID] – 21109728

Dermatology (Basel) 2011 Feb;222(1):49-58

BACKGROUND: Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments.

OBJECTIVE: To assess the efficacy and safety of a combination of oral rifampin, moxifloxacin and metronidazole in long-lasting refractory HS.

METHODS: We retrospectively studied 28 consecutive HS patients including 6, 10 and 12 Hurley stage 1, 2 and 3 patients, respectively. Complete remission, defined as a clearance of all inflammatory lesions including hypertrophic scars, was the main outcome criterion of the study.

RESULTS: Complete remission was obtained in 16 patients, including 6/6, 8/10 and 2/12 patients with Hurley stage 1, 2 and 3, respectively (p=0.0004). The median duration of treatment to obtain complete remission was 2.4 (range 0.9-6.5) and 3.8 months (range 1.6-7.4) in stage 1 and 2 patients, respectively, and 6.2 and 12 months in the 2 stage 3 patients. Main adverse events of the treatments were gastrointestinal disorders (64% of patients) and vaginal candidiasis (35% of females). Reversible tendinopathy and hepatitis occurred in 4 and 1 patient, respectively.

CONCLUSIONS: Complete remission of refractory HS can be obtained using broad-spectrum antibiotics and Hurley staging is a prognostic factor of response to the treatment.