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© Research
Publication : Journal of leukocyte biology

Distinct modes of TNF signaling through its two receptors in health and disease.

Team: Microenvironment and Immunity
Member: Kama Atretkhany
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of leukocyte biology - 01 Jun 2020

Atretkhany KN, Gogoleva VS, Drutskaya MS, Nedospasov SA

Link to Pubmed [PMID] – 32083339

Link to DOI – 10.1002/JLB.2MR0120-510R

J Leukoc Biol 2020 Jun; 107(6): 893-905

TNF is a key proinflammatory and immunoregulatory cytokine whose deregulation is associated with the development of autoimmune diseases and other pathologies. Recent studies suggest that distinct functions of TNF may be associated with differential engagement of its two receptors: TNFR1 or TNFR2. In this review, we discuss the relative contributions of these receptors to pathogenesis of several diseases, with the focus on autoimmunity and neuroinflammation. In particular, we discuss the role of TNFRs in the development of regulatory T cells during neuroinflammation and recent findings concerning targeting TNFR2 with agonistic and antagonistic reagents in various murine models of autoimmune and neuroinflammatory disorders and cancer.