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© Research
Publication : Virology

Detection by monoclonal antibodies of an antigenic determinant critical for poliovirus neutralization present on VP1 and on heat-inactivated virions

Team: Archived: Biology of Enteric Viruses
Member: Bruno Blondel
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virology - 30 Apr 1983

Blondel B, Akacem O, Crainic R, Couillin P, Horodniceanu F

Link to Pubmed [PMID] – 6190311

Virology 1983 Apr;126(2):707-10

Hybridoma cell lines were established against poliovirus type 1 (Mahoney) heat-denatured virions (C particles). Each anti-C monoclonal antibody (McAb) immunoprecipitated specifically one of the individualized poliovirus capsid polypeptides VP1, VP2, or VP3. One of the anti-C McAb (C-3), reacting with VP1, neutralized homologous virus and immunoprecipitated infectious D particles. Its properties have been compared to those of a neutralizing anti-D McAb (D-Ic). In contrast with the C-3 antigenic site, the D-Ic epitope was not present on C particles nor on individualized structural polypeptide. This demonstrates that C-3 and D-Ic epitopes represent two independent antigenic determinants, both critical for poliovirus neutralization.