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  • Director of Center
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© Research
Publication : Trends in molecular medicine

Death and the retrovirus

Team: Archived: Molecular Retrovirology
Team: Archived: Group: Jean-Pierre Vartanian
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in molecular medicine - 01 Oct 2003

Vartanian JP, Sommer P, Wain-Hobson S

Link to Pubmed [PMID] – 14557052

Trends Mol Med 2003 Oct;9(10):409-13

A flurry of new papers has shown that HIV reverse transcription is vulnerable to G–>A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.