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Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain

The splanchnopleura/AGM region is the prime site for the generation of multipotent hemopoietic precursors, in the mouse embryo

© Research

Publication : Antimicrobial agents and chemotherapy

Characterization of the Tn916-like transposon Tn3872 in a strain of abiotrophia defectiva (Streptococcus defectivus) causing sequential episodes of endocarditis in a child

Team: Archived: Group : Patrick Trieu-Cuot

Member: Patrick Trieu-Cuot

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Antimicrobial agents and chemotherapy - 01 Mar 2000

Poyart C, Quesne G, Acar P, Berche P, Trieu-Cuot P

Link to Pubmed [PMID] – 10681362

Antimicrob. Agents Chemother. 2000 Mar;44(3):790-3

Clinical blood isolates from three sequential episodes of endocarditis occurring over a 6-month period in a child with a malformative cardiopathy were investigated. All isolates identified as Abiotrophia defectiva were resistant to erythromycin-clindamycin and to tetracycline-minocycline, due to the presence of sequences homologous to the erythromycin resistance gene ermB and to the tetracycline resistance gene tet(M), respectively. These resistance genes were located on a chromosomally borne composite Tn916-related transposon. These results demonstrate the involvement of conjugative transposons in the dissemination of antibiotic resistance in the genus Abiotrophia.

Published on: 01 Mar 2000