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© Research
Publication : Cellular microbiology

Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract

Member: Philippe Sansonetti
Member: Benoît Marteyn
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular microbiology - 19 Dec 2010

Marteyn B, Scorza FB, Sansonetti PJ, Tang C

Link to Pubmed [PMID] – 21166974

Cell. Microbiol. 2011 Feb;13(2):171-6

The gastrointestinal tract provides a variety of environmental challenges to any bacterium seeking to successfully colonize or cause disease in a host. A major obstacle is the varied oxygen concentrations encountered at different sites in the intestine. Here we review the mechanisms bacterial pathogens utilize to sense oxygen within the gastrointestinal tract, and recent insights into how this acts as a signal to trigger virulence and to modulate host responses.