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© Research
Publication : American journal of human genetics

Biochemical and electrophoretic studies of erythrocyte pyridoxine kinase in white and black Americans

Team: Archived: Molecular Microbial Pathogenesis
Member: Benoît Marteyn
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in American journal of human genetics - 01 Jan 1976

Chern CJ, Beutler E

Link to Pubmed [PMID] – 2009

Am. J. Hum. Genet. 1976 Jan;28(1):9-17

The mean PNK activity in red blood cells from black subjects was only about 40% of that in whites. Among 51 whites examined, one was found to have enzyme deficiency. The estimated gene frequencies for PNKH (the common allele in whites which codes for higher enzyme activity) and PNKL (the common allele in blacks which codes for lower enzyme activity) were .35 and .65, respectively, for black donors, and .81 and .19, respectively, for white donors, The variant enzyme in persons with enzyme deficiency was associated with an increased rate of degradation in red cells during aging. No other biochemical or electrophoretic differences were detected.