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© Research
Publication : International immunology

B cell developmental defects in X-linked immunodeficiency

Member: Ana Cumano
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International immunology - 01 Feb 1993

Narendran A, Ramsden D, Cumano A, Tanaka T, Wu GE, Paige CJ

Link to Pubmed [PMID] – 7680896

Int. Immunol. 1993 Feb;5(2):139-44

We describe an analysis of early B cell development in mice with X linked immunodeficiency (Xid). It was found that, compared with the normal CBA/J strain, CBA/N (Xid/Xid) pre-B cells show an increased proliferative response to IL-7 but a decreased ability for subsequent maturation on stromal cells. However, the addition of mast cell growth factor largely restored the ability to mature in the presence of stromal cells. No anomalies were found in the rate of Ig heavy or light chain gene rearrangement in CBA/N cells despite their failure to undergo maturation. This suggests that these two events may occur independently.