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  • Undergraduate Student
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  • Director of Center
  • Director of Department
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© Research
Publication : PloS one

An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages

Member: Brigitte Gicquel
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 17 Aug 2010

Dasgupta A, Sureka K, Mitra D, Saha B, Sanyal S, Das AK, Chakrabarti P, Jackson M, Gicquel B, Kundu M, Basu J

Link to Pubmed [PMID] – 20808924

PLoS ONE 2010;5(8):e12225

The Mycobacterium tuberculosis genome encodes two peptide transporters encoded by Rv3665c-Rv3662c and Rv1280c-Rv1283c. Both belong to the family of ABC transporters containing two nucleotide-binding subunits, two integral membrane proteins and one substrate-binding polypeptide. However, little is known about their functions in M. tuberculosis. Here we report functional characterization of the Rv1280c-Rv1283c-encoded transporter and its substrate-binding polypeptide OppA(MTB).