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© Research
Publication : Clinical hemorheology and microcirculation

Abnormal flow adhesion of sickle red blood cells to human placental trophoblast extracellular matrix

Member: Stéphane Petres
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Clinical hemorheology and microcirculation - 01 Jan 2012

Lamarre Y, Petres S, Hardy-Dessources MD, Sinnapah S, Romana M, Laurance S, Lemonne N, Gysin J, Connes P

Link to Pubmed [PMID] – 22240382

Clin. Hemorheol. Microcirc. 2012;51(3):229-34

Pregnancy in sickle cell disease (SCD) has been associated with increased complications such as vaso-occlusive crises, severe anemia and foetal loss. It has been proposed that the sickling of red blood cells (RBCs) inside the placenta circulation could participate to these complications. The present study investigated the adhesion of sickle RBCs on human trophoblast-derived cell and its extracellular matrix. Results demonstrated 1) similar adhesion of sickle RBCs and healthy RBCs to trophoblast but 2) a greater adhesion of sickle RBCs to the extracellular matrix of trophoblasts as compared with healthy RBCs. This greater adhesion could partly involve the Lu/BCAM glycoproteins and could participate to the complications reported in SCD pregnant women.