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© Research
Publication : Journal of virology

A novel expression cassette of lyssavirus shows that the distantly related Mokola virus can rescue a defective rabies virus genome

Team: Archived: Antiviral Strategies
Team: Archived: Virus interactomics
Team: Archived: Molecular Genetics of RNA Viruses
Member: Noël Tordo
Member: Yves Jacob
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 01 Feb 2002

Le Mercier P, Jacob Y, Tanner K, Tordo N

Link to Pubmed [PMID] – 11799201

J. Virol. 2002 Feb;76(4):2024-7

By comparing three expression vectors for the rabies virus (Rv) minigenome, we show that the characteristic of the Rv RNA is important for efficient rescue despite its not being crucial for replication. Moreover, we show that the coexpression of the viral proteins from helper Rv and Mokola virus could rescue the Rv minigenome while Rv-related European bat lyssavirus 1 could not, suggesting that the signals controlling transcription and replication are conserved in the distantly related Rv and Mokola virus.