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© Research
Publication : The EMBO journal

A destabilised metabolic niche provokes loss of a subpopulation of aged muscle stem cells.

Team: Stem Cells And Development
Member: Brendan Evano
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The EMBO journal - 01 Dec 2019

Evano B, Tajbakhsh S,

Link to Pubmed [PMID] – 31797391

Link to DOI – 10.15252/embj.2019103924

EMBO J. 2019 12; 38(24): e103924

Ageing is a multi-factorial condition that results in a gradual decline in tissue and organ function. Systemic, local and intrinsic factors play major roles in this process that also results in a decline in stem cell number and function. In this issue of The EMBO Journal, Li et al (2019) show that a subpopulation of mouse muscle stem cells is depleted in aged mice through loss of niche-derived granulocyte colony-stimulating factor (G-CSF).