• 2025
  Jean Guillon, Solène Savrimoutou, Nicolas da Rocha, Sandra Albenque-Rubio, Olivier Helynck, Cyrielle Durand, Jeanne Chiaravalli, Noël Pinaud, Luisa Ronga, Stéphane Moreau, Simon Chirold, Tshering Zangmo, Melika Arab, Lindita Lari, Jean‐louis Mergny, Hélène Munier-Lehmann, Marc Lavigne, Design, synthesis, biophysical and biological evaluation of original condensed pyrrolopyrimidine and pyrrolopyridine ligands as anti-SARS-CoV-2 agents targeting G4, European Journal of Medicinal Chemistry, 2025, 292, pp.117655. ⟨10.1016/j.ejmech.2025.117655⟩.
• 2023
  Collados Rodríguez M, Maillard P, Journeaux A, Komarova AV, Najburg V, David RS, Helynck O, Guo M, Zhong J, Baize S, Tangy F, Jacob Y, Munier-Lehmann H, Meurs EF, Novel Antiviral Molecules against Ebola Virus Infection., Int J Mol Sci 2023 Sep; 24(19): .
• 2023
  Zhou Z, Staropoli I, Brelot A, Suzanne P, Lesnard A, Fontaine F, Perato S, Rault S, Helynck O, Arenzana-Seisdedos F, Sopkova-de Oliveira Santos J, Lagane B, Munier-Lehmann H, Colin P, Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands., Molecules 2023 Jan; 28(3): .
• 2022
  Magnotti F, Chirita D, Dalmon S, Martin A, Bronnec P, Sousa J, Helynck O, Lee W, Kastner DL, Chae JJ, McDermott MF, Belot A, Popoff M, Sève P, Georgin-Lavialle S, Munier-Lehmann H, Tran TA, De Langhe E, Wouters C, Jamilloux Y, Henry T, , Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism., Cell Rep 2022 Oct; 41(2): 111472.
• 2021
  Lavigne M, Helynck O, Rigolet P, Boudria-Souilah R, Nowakowski M, Baron B, Brülé S, Hoos S, Raynal B, Guittat L, Beauvineau C, Petres S, Granzhan A, Guillon J, Pratviel G, Teulade-Fichou MP, England P, Mergny JL, Munier-Lehmann H, SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction., Nucleic Acids Res 2021 Jul; 49(13): 7695-7712.
• 2021
  Le Vu S, Jones G, Anna F, Rose T, Richard JB, Bernard-Stoecklin S, Goyard S, Demeret C, Helynck O, Escriou N, Gransagne M, Petres S, Robin C, Monnet V, Perrin de Facci L, Ungeheuer MN, Léon L, Guillois Y, Filleul L, Charneau P, Lévy-Bruhl D, van der Werf S, Noel H, , Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance., Nat Commun 2021 05; 12(1): 3025.
• 2021
  Anna F, Goyard S, Lalanne AI, Nevo F, Gransagne M, Souque P, Louis D, Gillon V, Turbiez I, Bidard FC, Gobillion A, Savignoni A, Guillot-Delost M, Dejardin F, Dufour E, Petres S, Richard-Le Goff O, Choucha Z, Helynck O, Janin YL, Escriou N, Charneau P, Perez F, Rose T, Lantz O, , High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris., Eur J Immunol 2021 01; 51(1): 180-190.
• 2019
  Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H, First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
• 2018
  Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O, A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism, Antimicrob. Agents Chemother. 2018 Jun;62(6).
• 2017
  Dabo S., Maillard P., Collados Rodriguez M., Hansen M. D., Mazouz S., Bigot D. J., Tible M., Janvier G., Helynck O., Cassonnet P., Jacob Y., Bellalou J., Gatignol A., Patel R. C., Hugon J., Munier-Lehmann H., Meurs E. F., Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT, Sci Rep. 2017 Nov 23;7(1):16129.
• 2017
  Buchieri MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, Cascioferro A, Favre-Rochex S, Helynck O, Naud-Martin D, Larrouy-Maumus G, Munier-Lehmann H, Gicquel B, Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis, J. Med. Chem. 2017 Sep 14;60(17):7425-7433.
• 2017
  Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO, Original chemical series of pyrimidine biosynthesis inhibitors that boost the antiviral interferon response, Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17.
• 2015
  Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL, Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH), J. Med. Chem. 2015 Jul;58(14):5579-98.
• 2015
  Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL, Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH), J. Med. Chem. 2015 Jan;58(2):860-77.
• 2014
  Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO, High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses, J Vis Exp 2014;(87).
• 2013
  Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO, Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity, PLoS Pathog. 2013;9(10):e1003678.
• 2013
  Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C, Synergy of the antibiotic colistin with echinocandin antifungals in Candida species, J. Antimicrob. Chemother. 2013 Jun;68(6):1285-96.
• 2011
  Van Poecke S, Munier-Lehmann H, Helynck O, Froeyen M, Van Calenbergh S, Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase, Bioorg. Med. Chem. 2011 Dec;19(24):7603-11.