About
Exponentially increasing costs of pharmaceutical development – a phenomenon known as Eroom’s law – is a call for innovation. Here, we propose to integrate scattered genetic information on drug targets to guide their selection. During the past decade, the statistical genetic community discovered and replicated thousand variant-trait associations in human populations. Exploring this wealth of data, investigators recently revived the initial hopes for the potential of genetics to enhance drug development: drug targets with genetic evidence for efficacy (i.e. the target gene is linked to a variant significantly associated with the drug indication) have twice as much chance of success in a clinical trial. So far, previous efforts focused on European populations and sex and age aggregated data. In other domains of statistical genetics, such as polygenic risk scores, this sampling bias leads to a loss of accuracy in non-European ancestries. There is also mounting evidence of varying drug effects between sex and age strata. Yet, women and elderly are under-represented in randomized control trials. To document the genetic component of these drug effect variations and address these sampling biases, we will collect sex and age disaggregated data spanning all ancestries. Building upon this representative database, we will design a predictive algorithm to predict drug target efficacy from genetic information. The developed algorithm will be applied on all drug targets yet to be explored by pharmaceutical companies (which represent 2/3 of the 4479 druggable genes). In short, this project aims at summarizing genetic evidence for a drug target potential into a score relevant for all human population. By facilitating the prioritization of drug targets, we hope to transform Eroom’s law back into its well known reverse: Moore‘s law.
Your personal data: Information and specific rights
What is personal data?
Your personal data, including your health data, will be processed by Institut Pasteur in its capacity as data controller.
Personal data is information about you. This data enables us to know your identity:
- Either directly, through your name or address
- Or indirectly, through the use of a code in place of your identity.
Why is your personal data collected and who is responsible for it?
Institut Pasteur as the responsible party will carry out analyses with regard to the purposes presented in this document. This use is possible in accordance with Article 5 and Article 9 of the General Data Protection Regulation (GDPR) as the following conditions are met:
- it is necessary for scientific research purposes
- appropriate measures preserve the confidentiality of your information
- it meets a public health objective and therefore of public interest
What categories of personal data are involved?
Your personal data required for this scientific research are:
- your demographic data: age, gender,
- your health data: medical history and lab results,
- genetic data.
Data sources and processing by Institut Pasteur
The data processed are the genetic data of individuals who have consented to their data being shared to the scientific community in databases.
The personal data contained in these databases cannot be used to identify the individuals to whom they relate.
Moreover, this study of Institut Pasteur is being carried out after all the necessary procedures have been completed with the CNIL and the project has been registered on the Health Data Hub directory.
Only research laboratory staff may access the data required for the research, in compliance with the professional secrecy to which they are subject in accordance with article 226-13 of the French penal code. Access is granted for the duration of the research via the AllofUs and UKBiobank database platforms, without exporting personal data. Under no circumstances does Institut Pasteur have direct or indirect access to directly identifying data. At the end of the research, Institut Pasteur will only have access to aggregated and anonymous data that will not allow any re-identification.
The presentation of the results of this study will in no way enable the direct or indirect identification of the persons concerned. And no matching (cross-referencing) of results with other personal data is possible.
What are your data protection rights and how can you exercise it?
You can exercise the following rights with regard to your personal data:
- The right to request information about the processing of your data and to request a copy of it (right of access);
- The right to request the rectification of data concerning you if it is inaccurate or incomplete; while we examine your request, you have the right to restrict the processing of your data;
- The right to object to the processing of your data for scientific research purposes at any time and without having to justify your decision;
- If you object to the processing of your data; you may request the deletion of your data already collected when such data is no longer required. However, certain previously collected data may not be deleted if their deletion is likely to make it impossible or seriously compromise the achievement of the purpose of the study or to satisfy a legal obligation.
To exercise your rights as described above, you may contact Institut Pasteur’s Data Protection Officer by e-mail, specifying the name of the research concerned (MooreForAll), at the following address dpo@pasteur.fr .
If you do not receive a reply within one month, or if you dispute the reply, you have the right to contact the Commission Nationale de l’Informatique et des Libertés (CNIL), the French data protection supervisory authority: CNIL – 3 place de Fontenoy – TSA 80715 -75334 Paris cedex 07 – telephone number : 00 33 1 53 73 22 22 – http://www.cnil.froy – TSA 80715 -75334 Paris cedex 07 – telephone number : 00 33 1 53 73 22 22 – http://www.cnil.fr
