“Protection against malaria is induced by blood stage-arresting Histamine Releasing Factor (HRF)-deficient Plasmodium parasites” | Research - Institut Pasteur

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Milieu Intérieur Scientific Advisory Board

Trypanosomatid parasites: From the Field to the Lab. IV

Scientific Fields

Diseases

Organisms

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Technique

Date

28

Jan 2016

Time

12:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

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Building: Lwoff

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2016-01-28 12:00:00 2016-01-28 13:00:00 Europe/Paris “Protection against malaria is induced by blood stage-arresting Histamine Releasing Factor (HRF)-deficient Plasmodium parasites” Claudia DEMARTA-GATSI – Unité de Biologie des interactions hôte-parasite (BIHP) Whole parasite vaccines such as genetically attenuated parasite (GAP) vaccines that induce cross-stage, long-lasting sterile protection have become the state-of-the-art to target malaria for […] Institut Pasteur, Rue du Docteur Roux, Paris, France

About

Claudia DEMARTA-GATSI – Unité de Biologie des interactions hôte-parasite (BIHP)

Whole parasite vaccines such as genetically attenuated parasite (GAP) vaccines that induce cross-stage, long-lasting sterile protection have become the state-of-the-art to target malaria for elimination. Utilizing the P. berghei NK65 strain, which causes severe malaria in rodents, we deleted the histamine-releasing factor (hrf) gene and observed the elimination of the parasite, during the blood stage, through the development of an efficient immune response. Analysis on the innate and acquired immune responses to PbNK65-hrfΔ infection highlighted the role of the cytokine IL-6, the PD1 receptor expressed by CD4⁺ and CD8⁺ T cells, and B cell activation with antigen specific-antibody production. The results indicate that the PbNK65-hrfΔ GAPs can be recommended as effective blood stage malaria vaccines, strengthening the arsenal of the war against lethal Plasmodium parasites.

Contact : Luisa NARDINI (luisa.nardini@pasteur.fr)

Location

Building: Lwoff
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 25 Jan 2016 • Modified on: 25 Sep 2017

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