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© Research
Publication : Antibiotics (Basel, Switzerland)

Cefiderocol in Critically Ill Patients with Multi-Drug Resistant Pathogens: Real-Life Data on Pharmacokinetics and Microbiological Surveillance.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antibiotics (Basel, Switzerland) - 28 May 2021

König C, Both A, Rohde H, Kluge S, Frey OR, Röhr AC, Wichmann D

Link to Pubmed [PMID] – 34071700

Link to DOI – 10.3390/antibiotics10060649

Antibiotics (Basel) 2021 May; 10(6):

Cefiderocol is a new siderophore-cephalosporin for the treatment of multi-drug resistant Gram-negative pathogens. As a reserve agent, it will and should be used primarily in critically ill patients in the upcoming years. Due to the novelty of the substance little data on the pharmacokinetics in critically ill patients with septic shock and renal failure (including continuous renal replacement therapy and cytokine adsorber therapy) is available. We performed therapeutic drug monitoring in a cohort of five patients treated with cefiderocol, to improve the knowledge on pharmacokinetics in this vulnerable patient population. As expected for a cephalosporin with predominantly renal elimination the maintenance dose could be reduced in patients with renal impairment or on continuous renal replacement therapy. The manufacturer’s dosing instructions were sufficient to achieve a drug level well above the MIC. However, the addition of a cytokine adsorber might reduce serum levels substantially, so that in this context therapeutic drug monitoring and dose adjustment are recommended.