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© Research
Publication : Science advances

Structure and host specificity of Staphylococcus epidermidis bacteriophage Andhra.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science advances - 02 Dec 2022

Hawkins NC, Kizziah JL, Hatoum-Aslan A, Dokland T,

Link to Pubmed [PMID] – 36449623

Link to DOI – eade045910.1126/sciadv.ade0459

Sci Adv 2022 Dec; 8(48): eade0459

Staphylococcus epidermidis is an opportunistic pathogen of the human skin, often associated with infections of implanted medical devices. Staphylococcal picoviruses are a group of strictly lytic, short-tailed bacteriophages with compact genomes that are attractive candidates for therapeutic use. Here, we report the structure of the complete virion of S. epidermidis-infecting phage Andhra, determined using high-resolution cryo-electron microscopy, allowing atomic modeling of 11 capsid and tail proteins. The capsid is a T = 4 icosahedron containing a unique stabilizing capsid lining protein. The tail includes 12 trimers of a unique receptor binding protein (RBP), a lytic protein that also serves to anchor the RBPs to the tail stem, and a hexameric tail knob that acts as a gatekeeper for DNA ejection. Using structure prediction with AlphaFold, we identified the two proteins that comprise the tail tip heterooctamer. Our findings elucidate critical features for virion assembly, host recognition, and penetration.