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© Research
Publication : Viruses

Crosstalk between Hepatitis B Virus and the 3D Genome Structure.

Team: Spatial Regulation of Genomes
Member: Romain Koszul
Member: Axel Cournac
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Viruses - 21 Feb 2022

Dias JD, Sarica N, Cournac A, Koszul R, Neuveut C,

Link to Pubmed [PMID] – 35216038

Link to DOI – 44510.3390/v14020445

Viruses 2022 02; 14(2):

Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization.