I did my PhD at the Institut Cochin (France) in the laboratory of Bénédicte Chazaud where I analysed the interactions between macrophages and muscle cellular environment in human and mice. Then I moved to the laboratory of Graziella Messina in Milan (Italy) to study the function of the transcription factor Nfix in macrophages phenotype and behavior after acute muscle injury and in degenerative myopathies. These works demonstrated that, depending on the environmental context, macrophages can be benefic or deleterious to tissue recovery. I joined the laboratory of Han Li to decipher the cellular communication between senescent cells and macrophages during muscle repair and in pathological degeneration.
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Timeline
Projects
CV
Research Experience
2022/01 – present Postdoctoral fellow – Institut Pasteur, Paris, France
Project: “Interaction between senescent cells and macrophages”
Laboratory of Han Li, Team “Cellular plasticity in age-related pathologies”
2014/07 – 2021/02 Postdoctoral fellow – Università degli Studi di Milano, Milan, Italy
Project: “Molecular function of Nfix in macrophages during acute and chronic injury”
Laboratory of Graziella Messina, Team “Development, differentiation and therapies”
2011/01 – 2014/03 PhD student – Institut Cochin, Paris, France
PhD Project: “Functional phenotyping of macrophage subsets during skeletal muscle regeneration and in degenerative myopathies”
Laboratory of Bénédicte Chazaud, Team “Stem Cell Environment and Skeletal Muscle Homeostasis”
Funding of Research Projects
As Principal Investigator
2024 Postdoc Seed-Grant launched by SPAIS/Postdoc Office of the Institut Pasteur, won with Juan Diego Hernandez Camacho (Postdoc at Institut Pasteur in Timothy Wai Lab) – 12 600€ for 6 months, “Mitochondria, Stem cell and Macrophages”.
Fellowships awarded to myself (salary grants)
2025 Post-doctoral fellowship financed by AFM-Téléthon, “Impact of Senescent Cell-Macrophage Crosstalk in Muscle Repair”
2022 Post-doctoral fellowship financed by LabEx Revive, Regenerative biology & medicine – 95 640€ for 2 years, “Deciphering the Cellular Communication between Senescent Cells and Macrophages during muscle regeneration and degeneration”
2017 Post-doctoral fellowship financed by the University of Milan, Assegno di ricerca tipo A – 42 000€ for 2 years, “Dual functions of Nfix in Macrophages”
Publications
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2024MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet., iScience 2024 Jan; 27(1): 108696.
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2023Single-cell RNAseq reveals the pro-regenerative role of senescent FAPs in muscle regeneration, 2025.
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2023A chromosome-level reference genome and pangenome for barn swallow population genomics., Cell Rep 2023 Jan; 42(1): 111992.
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2022Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis., J Pathol 2022 Jul; 257(3): 352-366.
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2022Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner., J Neuromuscul Dis 2022 ; 9(1): 1-23.
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2021The transcription factor NF-Y participates to stem cell fate decision and regeneration in adult skeletal muscle., Nat Commun 2021 Oct; 12(1): 6013.
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2021Interplay between myofibers and pro-inflammatory macrophages controls muscle damage in mdx mice., J Cell Sci 2021 Sep; 134(18): .
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2021Rebalancing expression of HMGB1 redox isoforms to counteract muscular dystrophy., Sci Transl Med 2021 Jun; 13(596): .
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2021Histological Analysis of Tibialis Anterior Muscle of DMDmdx4Cv Mice from 1 to 24 Months., J Neuromuscul Dis 2021 ; 8(4): 513-524.
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2020The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration., Cells 2020 Mar; 9(3): .
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