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© Research
Publication : Cell death and differentiation

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients.

Team: U1306 – Host-Microbe interactions and pathophysiology
Team: Biology and Genetics of Bacterial Cell Wall
Member: Ivo Gomperts Boneca
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell death and differentiation - 01 May 2021

Picard M, Yonekura S, Slowicka K, Petta I, Rauber C, Routy B, Richard C, Iebba V, Tidjani Alou M, Becharef S, Ly P, Pizzato E, Lehmann CHK, Amon L, Klein C, Opolon P, Gomperts Boneca I, Scoazec JY, Hollebecque A, Malka D, Ghiringhelli F, Dudziak D, Berx G, Vereecke L, van Loo G, Kroemer G, Zitvogel L, Roberti MP

Link to Pubmed [PMID] – 33262469

Link to DOI – 10.1038/s41418-020-00684-w

Cell Death Differ 2021 May; 28(5): 1532-1547

Ileal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum-tumor axis, influencing clinical outcome.