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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : Human vaccines & immunotherapeutics

Immunogenicity and safety among laboratory workers vaccinated with Bexsero® vaccine.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Human vaccines & immunotherapeutics - 03 Nov 2016

Hong E, Terrade A, Taha MK,

Link to Pubmed [PMID] – 27808594

Link to DOI – 10.1080/21645515.2016.1241358

Hum Vaccin Immunother 2017 03; 13(3): 645-648

Neisseria meningitidis serogroup B is the most prevalent cause of invasive meningococcal disease in Europe and members of laboratories working on meningococci are at risk due to frequent handling. Recommendation for anti-meningococcal vaccination among these workers has been recently updated upon the licensure in Europe of Bexsero® vaccine. We tested the immunogenicity and safety of this vaccine among adults laboratory staff using the recommended schedule of 2 doses at 5 weeks interval. The vaccine was well tolerated in spite of frequent local side effects and all participants reported at least one side effect after each dose. Immunogenicity was evaluated 6 weeks and one year after the second dose. All participants showed increase in their bactericidal titers against the components of the vaccine 6 weeks after the second dose, however titers declined significantly one year later.