Sigma L is important for cold shock adaptation of Bacillus subtilis | Research - Institut Pasteur

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[Prevalence of community-acquired methicillin-résistant Staphylococcus aureus]

Reinforcing effects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors

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Published in Journal of bacteriology - 01 Apr 2006

Wiegeshoff F, Beckering CL, Debarbouille M, Marahiel MA

Link to Pubmed [PMID] – 16585774

J. Bacteriol. 2006 Apr;188(8):3130-3

Although sigma factor-dependent transcriptional regulation was shown to be essential for adaptation to different environmental stimuli, no such sigma factor has been related to the regulation of the cold shock response in Bacillus subtilis. In this study, we present genetic evidence for participation of sigma(L) (sigma(54)) and the two sigma(L)-dependent transcriptional enhancers BkdR and YplP in the cold shock response of Bacillus subtilis JH642. Single-gene deletion of either sigL, bkdR, or yplP resulted in a cold-sensitive phenotype.

Published on: 01 Apr 2006