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© Research
Publication : Viral immunology

Effector T lymphocytes present in demyelinating lesions induced by Theiler’s virus

Member: Antonio Bandeira Ferreira
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Viral immunology - 01 Jan 1991

Cash E, Bandeira A

Link to Pubmed [PMID] – 1676589

Viral Immunol. 1991;4(1):53-7

Theiler’s virus causes chronic primary demyelination associated with viral persistence in SJL/J mice. We have investigated the effector functions of T lymphocytes isolated from inflammatory brain lesions to detect a local immune dysfunction associated with viral persistence. In vitro, CD4+ T cells induced B-lymphocyte proliferation and antibody secretion; CD8+ T cells had cytolytic activity. Therefore, Theiler’s virus persistence does not include local immune unresponsiveness.