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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Expression of alpha v and beta 3 integrin chains on murine lymphocytes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 10 Dec 1996

Gerber DJ, Pereira P, Huang SY, Pelletier C, Tonegawa S

Link to Pubmed [PMID] – 8962117

Proc. Natl. Acad. Sci. U.S.A. 1996 Dec;93(25):14698-703

The vitronectin receptor is a member of the integrin family of adhesion protein receptors and binds a broad spectrum of ligands, including fibronectin and fibrinogen in addition to vitronectin. We have generated four mAbs that recognize the murine alpha v beta 3 vitronectin receptor. Biochemical and expression analyses showed that two of the mAbs are specific for the alpha v chain, and two are specific for the beta 3 chain. The mAbs are effective blocking reagents and inhibited cell adhesion to vitronectin, fibrinogen, and fibronectin. Staining analysis revealed expression of alpha v and beta 3 on certain populations of murine thymocytes, splenocytes, and bone marrow cells. The expression of alpha v and beta 3 appeared to be modulated at specific stages of thymocyte development, suggesting a possible function for the alpha v beta 3 vitronectin receptor in T cell development.