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© Research
Publication : Developments in biological standardization

Mapping of type 1 poliovirus neutralization epitopes

Team: Archived: Biology of Enteric Viruses
Member: Bruno Blondel
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developments in biological standardization - 01 Jan 1985

Blondel B, Crainic R, Dufraisse G, Candréa A, Horaud F

Link to Pubmed [PMID] – 2412917

Dev. Biol. Stand. 1985;60:337-42

Several independently variable neutralization epitopes were identified on type 1 poliovirus by testing various field isolates with a panel of homotypic monoclonal antibodies. According to their distribution among viruses tested, neutralization epitopes were classified as strain-specific or variable (V) and cross-reacting or constant (K). Operational, relationship between different neutralization epitopes was analysed by selecting mutants resistant to neutralization with monoclonal antibodies from wild Mahoney and attenuated Sabin type 1 poliovirus. The results of this study and their implication in the characterization of poliovirus antigenic structure by neutralization epitope formulae is discussed.