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© Research
Publication : Travel medicine and infectious disease

Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon

Team: Epidemiology of Emerging Diseases
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Travel medicine and infectious disease - 02 Apr 2008

Gallien S, Taieb F, Schlemmer F, Lagrange-Xelot M, Atlan A, Sarfati C, Molina JM

Link to Pubmed [PMID] – 18486067

Travel Med Infect Dis 2008 May;6(3):128-9

We report a case of a patient returning from Cameroon who developed Plasmodium ovale malaria, despite atovaquone/proguanil (AP, Malarone) prophylaxis, which is widely used for the prevention of chloroquine-resistant malaria. AP is indeed active only on schizont blood forms of P. ovale but not against liver-stage hypnozoites and does not realize effective prophylaxis against delayed onset of P. ovale malaria. Hence, this case illustrates the risk of failure with Malarone for the prophylaxis of P. ovale infection for travelers in endemic regions. Travelers returned from risk areas with symptoms suggestive of malaria, should not have the diagnosis of P. ovale (or P. vivax) infection discounted, despite a history of compliance with a standard chemoprophylactic regimen.