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© Research
Publication : Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie

[Inhibition of the tumoral growth induced by the injection of histo-incompatible cells producing interleukin-2]

Team: Ecology and Emergence of Arthropod-borne Pathogens
Member: Claude Roth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie - 01 Jan 1992

Roth C, Mir LM, Cressent M, Quintin-Colonna F, Belehradek J, Ley V, Fradelizi D, Kourilsky P

Link to Pubmed [PMID] – 1521169

C. R. Acad. Sci. III, Sci. Vie 1992;314(11):499-504

In murine models, we show that the growth of a transplanted tumor can be controlled when allogeneic or xenogeneic cells expressing high levels of interleukin-2 are co-injected with the syngeneic tumor cells. Thus, genetically modified allogeneic or xenogeneic cells could have some therapeutic potential as vectors for transient cytokine gene expression.