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© Charles Dauguet
Virus VIH-1 (HIV-1), agent du sida, à la surface d'un lymphocyte. Image colorisée.
Publication : AIDS (London, England)

Secretory IgA specific for MPER can protect from HIV-1 infection in vitro

Team: Group: MISTIC
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in AIDS (London, England) - 31 Jul 2013

Benjelloun F, Dawood R, Urcuqui-Inchima S, Rochereau N, Chanut B, Verrier B, Lucht F, Genin C, Paul S

Link to Pubmed [PMID] – 23696073

AIDS 2013 Jul;27(12):1992-5

This preliminary study was performed to assess the neutralization activity of anti-MPER-secretory IgA (SIgA) from parotid saliva in 88 HIV+ patients, in five exposed seronegative (ESN) and in five seronegative volunteers. 48.9% of the HIV+ patients and 100% of ESN patients showed antigp41 SIgA. 25.6% of anti-MPER SIgA from HIV+ patients and 100% from ESN patients neutralized efficiently HIV-1 primary isolate SF162 (IC 50). The neutralization activity is maintained for much lower concentrations in ESN than in HIV+ secretions.