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© Research
Publication : Nature

Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

Team: Archived: Molecular Microbial Pathogenesis
Team: Group : Régis Tournebize
Team: Archived: Imagopole
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature - 01 Aug 1996

Heald R, Tournebize R, Blank T, Sandaltzopoulos R, Becker P, Hyman A, Karsenti E

Link to Pubmed [PMID] – 8684481

Nature 1996 Aug;382(6590):420-5

Functional nuclei and mitotic spindles are shown to assemble around DNA-coated beads incubated in Xenopus egg extracts. Bipolar spindles assemble in the absence of centrosomes and kinetochores, indicating that bipolarity is an intrinsic property of microtubules assembling around chromatin in a mitotic cytoplasm. Microtubules nucleated at dispersed sites with random polarity rearrange into two arrays of uniform polarity. Spindle-pole formation requires cytoplasmic dynein-dependent translocation of microtubules across one another. It is proposed that spindles form in the absence of centrosomes by motor-dependent sorting of microtubules according to their polarity.