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© Research
Publication : Journal of medical virology

Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad

Team: Archived: Molecular Genetics of RNA Viruses
Member: Vincent Enouf
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of medical virology - 01 Dec 2005

Nicand E, Armstrong GL, Enouf V, Guthmann JP, Guerin JP, Caron M, Nizou JY, Andraghetti R

Link to Pubmed [PMID] – 16254969

J. Med. Virol. 2005 Dec;77(4):519-21

The within-outbreak diversity of hepatitis E virus (HEV) was studied during the outbreak of hepatitis E that occurred in Sudan in 2004. Specimens were collected from internally displaced persons living in a Sudanese refugee camp and two camps implanted in Chad. A comparison of the sequences in the ORF2 region of 23 Sudanese isolates and five HEV samples from the two Chadian camps displayed a high similarity (>99.7%) to strains belonging to Genotype 1. But four isolates collected in one of the Chadian camps were close to Genotype 2. Circulation of divergent strains argues for possible multiple sources of infection.