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The N-terminal domain of hepatocyte growth factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c-met receptor

Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity

© Research

Publication : Genes to cells : devoted to molecular & cellular mechanisms

High dosage Rhp51 suppression of the MMS sensitivity of DNA structure checkpoint mutants reveals a relationship between Crb2 and Rhp51

Team: Dynamics of the Genome

Member: Stefania Francesconi

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Genes to cells : devoted to molecular & cellular mechanisms - 01 Jul 2003

Smeets MF, Francesconi S, Baldacci G

Link to Pubmed [PMID] – 12839619

Genes Cells 2003 Jul;8(7):573-86

In eukaryotic cells DNA structure checkpoints organize the cellular responses of DNA repair and transient cell cycle arrest and thereby ensure genomic stability. To investigate the exact role of crb2+ in the DNA damage checkpoint response, a genetic screen was carried out in order to identify suppressors of the conditional MMS sensitivity of a crb2-1 mutant. Here we report the isolation of rhp51+ as a multicopy suppressor.

Published on: 01 Jul 2003