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© Research
Publication : Helicobacter

Deficiency in OGG1 protects against inflammation and mutagenic effects associated with H. pylori infection in mouse

Team: Group: Infection, Genotoxicity and Cancer
Team: Archived: Helicobacter Pathogenesis
Member: Eliette Touati
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Helicobacter - 01 Oct 2006

Touati E, Michel V, Thiberge JM, Avé P, Huerre M, Bourgade F, Klungland A, Labigne A

Link to Pubmed [PMID] – 16961812

Helicobacter 2006 Oct;11(5):494-505

Helicobacter pylori infection is associated with gastric cancer. Study with the Big Blue mouse model has reported a mutagenic effect associated with the H. pylori infection, as a result in part of oxidative DNA damage. The present work investigates the consequences of a deficiency in the OGG1 DNA glycosylase, responsible for the excision of 8-oxo guanine, on the inflammatory and genotoxic host response to the infection.