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© Olivier Schwartz, Institut Pasteur
Publication : Trends in immunology

Tailored immunogens for rationally designed antibody-based HIV-1 vaccines

Team: Humoral Immunology
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in immunology - 11 Jul 2015

Mouquet H

Link to Pubmed [PMID] – 26169255

Trends Immunol. 2015 Jul;

Protective HIV-1 vaccines would require the induction of broadly neutralizing antibodies (bNAbs) to be effective against the vast diversity of circulating viral strains. Three new studies provide in vivo demonstration that rational design of vaccine strategies using engineered and native-like HIV-1 immunogens can be exploited for guiding B-cell evolution towards the genesis of HIV-1 bNAbs.