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© Research
Publication : Science (New York, N.Y.)

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

Team: Archived: Molecular Retrovirology
Team: Archived: Group: Jean-Pierre Vartanian
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 11 Apr 2008

Vartanian JP, Guétard D, Henry M, Wain-Hobson S

Link to Pubmed [PMID] – 18403710

Science 2008 Apr;320(5873):230-3

Cytidine deaminases of the APOBEC3 family all have specificity for single-stranded DNA, which may become exposed during replication or transcription of double-stranded DNA. Three human APOBEC3A (hA3A), hA3B, and hA3H genes are expressed in keratinocytes and skin, leading us to determine whether genetic editing of human papillomavirus (HPV) DNA occurred. In a study of HPV1a plantar warts and HPV16 precancerous cervical biopsies, hyperedited HPV1a and HPV16 genomes were found. Strictly analogous results were obtained from transfection experiments with HPV plasmid DNA and the three nuclear localized enzymes: hA3A, hA3C, and hA3H. Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors.