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© Research
Publication : Methods in molecular biology (Clifton, N.J.)

Scoring sporozoite motility

Team: Archived: Malaria Biology and Genetics
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Methods in molecular biology (Clifton, N.J.) - 01 Jan 2013

Carey AF, Ménard R, Bargieri DY

Link to Pubmed [PMID] – 22990792

Methods Mol. Biol. 2013;923:371-83

Sporozoites, the stage of Plasmodium infectious to vertebrates when injected in the skin by a mosquito vector, are highly motile cells. Their unusual form of gliding motility is essential for infectivity, allowing the parasite to travel through both the mosquito and mammalian hosts, invading different cell types and escaping immune cell-mediated death. In this chapter, we describe techniques to study gliding motility of sporozoites in vitro and in vivo.