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© Research
Publication : FEMS immunology and medical microbiology

Ten years after the first Helicobacter pylori genome: comparative and functional genomics provide new insights in the variability and adaptability of a persistent pathogen

Team: Archived: Helicobacter Pathogenesis
Member: Hilde De Reuse
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEMS immunology and medical microbiology - 01 Jul 2007

de Reuse H, Bereswill S

Link to Pubmed [PMID] – 17567280

FEMS Immunol. Med. Microbiol. 2007 Jul;50(2):165-76

In this review, we summarize how genomic approaches contributed to the understanding of the biology of the recently discovered pathogen Helicobacter pylori. Comparative genomics provided new insights into H. pylori’s spectacular genetic diversity and generated exiting hypotheses on its evolutionary history. Transcriptomic studies provided original information on the mechanisms of H. pylori gastric adaptation that are central to its virulence.