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© Research
Publication : PloS one

Trans-translation in Helicobacter pylori: essentiality of ribosome rescue and requirement of protein tagging for stress resistance and competence

Team: Archived: Helicobacter Pathogenesis
Member: Hilde De Reuse
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 26 Nov 2008

Thibonnier M, Thiberge JM, De Reuse H

Link to Pubmed [PMID] – 19043582

PLoS ONE 2008;3(11):e3810

The ubiquitous bacterial trans-translation is one of the most studied quality control mechanisms. Trans-translation requires two specific factors, a small RNA SsrA (tmRNA) and a protein co-factor SmpB, to promote the release of ribosomes stalled on defective mRNAs and to add a specific tag sequence to aberrant polypeptides to direct them to degradation pathways. Helicobacter pylori is a pathogen persistently colonizing a hostile niche, the stomach of humans.