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© Research
Publication : Antimicrobial agents and chemotherapy

TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511

Team: Archived: Antibacterial Agents
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 Nov 2002

Alonso R, Gerbaud G, Galimand M, Courvalin P

Link to Pubmed [PMID] – 12384377

Antimicrob. Agents Chemother. 2002 Nov;46(11):3627-9

Clinical isolate Escherichia coli BM4511 was resistant to broad-spectrum penicillins in the presence or in the absence of beta-lactamase inhibitors but remained susceptible to cephalosporins. Resistance was due to production of a new TEM-type beta-lactamase, designated TEM-103/IRT-28, characterized by the Arg(275)Leu substitution and encoded by the ca. 62-kb pIP845 conjugative plasmid of the IncI1 incompatibility group.