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Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.

First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme

© Research

Publication : Antimicrobial agents and chemotherapy

RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family

Team: Archived: Antibacterial Agents

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Diseases

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Published in Antimicrobial agents and chemotherapy - 30 Apr 2012

Galimand M, Courvalin P, Lambert T

Link to Pubmed [PMID] – 22547620

Antimicrob. Agents Chemother. 2012 Jul;56(7):3960-2

Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6′)-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of aminoglycoside resistance 16S rRNA methyltransferases.

Published on: 30 Apr 2012