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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Publication : Cell cycle (Georgetown, Tex.)

SUMO is growing senescent

Team: Nuclear Organization and Oncogenesis
Member: Anne Dejean
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell cycle (Georgetown, Tex.) - 20 Mar 2007

Bischof O, Dejean A

Link to Pubmed [PMID] – 17374992

Cell Cycle 2007 Mar;6(6):677-81

Cellular senescence is an irreversible cell cycle arrest that curbs unrestrained, aberrant proliferation of mammalian cells and is now recognized as a prominent tumor suppressive mechanism. We have shown recently that the E3 SUMO ligase PIASy actively contributes to execution of the senescence program, thus, providing the first evidence for a direct role of SUMO modification in this process. Here, we discuss some of the implications for this novel connection and future directions to study in more detail the importance of the SUMO pathway in senescence and tumorigenesis.