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© Research
Publication : PloS one

Lipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cells

Team: Membrane Traffic and Pathogenesis
Member: Chiara Zurzolo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 08 Jun 2009

Sarnataro D, Caputo A, Casanova P, Puri C, Paladino S, Tivodar SS, Campana V, Tacchetti C, Zurzolo C

Link to Pubmed [PMID] – 19503793

PLoS ONE 2009;4(6):e5829

The cellular prion protein (PrP(C)) plays a key role in the pathogenesis of Transmissible Spongiform Encephalopathies in which the protein undergoes post-translational conversion to the infectious form (PrP(Sc)). Although endocytosis appears to be required for this conversion, the mechanism of PrP(C) internalization is still debated, as caveolae/raft- and clathrin-dependent processes have all been reported to be involved.