“Mother & Child Health” Seminar: Stress-responsive pathways in pathophysiological prenatal brain development - Research - Institut Pasteur

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Innovation Seminar: Startup Breakfast with M.Matthieu Goutet, Sofinnova Partner

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18

Jun 2025

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11:00:00

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Building: J. Monod Room: Amphi. Agnes Ullmann

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2025-06-18 11:00:00 2025-06-18 12:00:00 Europe/Paris “Mother & Child Health” Seminar: Stress-responsive pathways in pathophysiological prenatal brain development The Development and Environment Interface team led by Valérie Mezger studies the impact of stress on cell identity. We aim to understand how prenatal stress perturbs neural cell fate and therefore contributes to neurodevelopmental disorders (NDDs) through transcriptomic and […] Philippe Sansonetti philippe.sansonetti@pasteur.fr

Speakers

Valérie MEZGER

(Research Center « Epigenetics and Cell Fate » UMR7216 Head of the Team « Interface between Development and Environment » Université Paris Cité)

About

The Development and Environment Interface team led by Valérie Mezger studies the impact of stress on cell identity. We aim to understand how prenatal stress perturbs neural cell fate and therefore contributes to neurodevelopmental disorders (NDDs) through transcriptomic and epigenetic components of stress responses toshape normal and pathological neurodevelopment. For this, we focus on stressors of prenatal relevance (prenatal alcohol exposure or neuroinflammation, induced by infections), which are major causes of non-genetic NDDs and combines the use of mouse models and human cerebral organoids to single-cell multi-omics approaches. The team demonstrated that deregulation of stress-responses is also observed in monogenic NDDs and therefore have developed a transfer project and collaborations with mathematicians in deep learning to build therapeutic strategies.

Interested scientists who would like to discuss with the speaker can contact Hafida.fsihi@pasteur.fr to arrange a meeting.

Published on: 10 Jun 2025

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