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© Research
Publication : Science (New York, N.Y.)

Sexual dimorphism in skin immunity is mediated by an androgen-ILC2-dendritic cell axis.

Team: Meta-organism
Member: Nicolas Bouladoux
Member: Yasmine Belkaid
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 12 Apr 2024

Chi L, Liu C, Gribonika I, Gschwend J, Corral D, Han SJ, Lim AI, Rivera CA, Link VM, Wells AC, Bouladoux N, Collins N, Lima-Junior DS, Enamorado M, Rehermann B, Laffont S, Guéry JC, Tussiwand R, Schneider C, Belkaid Y

Link to Pubmed [PMID] – 38574174

Link to DOI – 10.1126/science.adk6200

Science 2024 Apr; 384(6692): eadk6200

Males and females exhibit profound differences in immune responses and disease susceptibility. However, the factors responsible for sex differences in tissue immunity remain poorly understood. Here, we uncovered a dominant role for type 2 innate lymphoid cells (ILC2s) in shaping sexual immune dimorphism within the skin. Mechanistically, negative regulation of ILC2s by androgens leads to a reduction in dendritic cell accumulation and activation in males, along with reduced tissue immunity. Collectively, our results reveal a role for the androgen-ILC2-dendritic cell axis in controlling sexual immune dimorphism. Moreover, this work proposes that tissue immune set points are defined by the dual action of sex hormones and the microbiota, with sex hormones controlling the strength of local immunity and microbiota calibrating its tone.