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© Institut Pasteur - Photo by Perrine Bomme, Lise Chauveau & Olivier Schwartz, colorized by Jean-Marc Panaud
Cellule dendritique vue en microscopie électronique à balayage. Les cellules dendritiques sont cellules importantes de l'immunité. Elles sont indispensables à la mise en place de défenses contre les agents infectieux, les tumeurs ou les maladies auto-immunes. Elles interviennent également dans les processus de tolérance de greffes.
Publication : Current opinion in immunology

Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 01 Feb 2007

Vascotto F, Le Roux D, Lankar D, Faure-André G, Vargas P, Guermonprez P, Lennon-Duménil AM

Link to Pubmed [PMID] – 17140785

Curr Opin Immunol 2007 Feb; 19(1): 93-8

Antigen capture and presentation onto MHC class II molecules by B lymphocytes is mediated by their surface antigen receptor – the B-cell receptor (BCR). The BCR must therefore coordinate the transport of MHC class II- and antigen-containing vesicles for them to converge and ensure efficient processing. Recently, progress has been made in understanding which and how these vesicular transport events are molecularly linked to BCR signaling. In particular, recent studies have emphasized the key roles of membrane microdomains and the actin cytoskeleton in regulation of membrane trafficking upon BCR engagement.