Timeline

25 Aug 2018

patent

Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri

01 Nov 2016

publication

Heparan sulfate differentially controls CXCL12α- and CXCL12γ-mediated cell migration through differential presentation to their receptor CXCR4

10 Oct 2016

publication

CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge

01 Aug 2014

publication

Well-defined biomimetic surfaces to characterize glycosaminoglycan-mediated interactions on the molecular, supramolecular and cellular levels

28 Jun 2013

publication

Mucin-like peptides from Echinococcus granulosus induce antitumor activity

03 Oct 2012

publication

Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12/proteoglycan interactions

04 Jun 2012

publication

CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension

16 Mar 2012

publication

Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain

27 Jan 2012

publication

A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti- HIV-1 activity independently of coreceptor usage

23 Jul 2011

publication

Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO

15 Apr 2011

publication

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

01 Feb 2010

publication

Slightly modifying pseudoproline dipeptides incorporation strategy enables solid phase synthesis of a 54 AA fragment of caveolin-1 encompassing the intramembrane domain

06 Sep 2009

publication

A synthetic CD4-heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry

28 Aug 2009

publication

Glycosaminoglycan mimetics inhibit SDF-1/CXCL12-mediated migration and invasion of human hepatoma cells

17 Aug 2009

publication

Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells

20 Apr 2009

publication

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

16 Sep 2008

publication

Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (SDF-1/CXCL 12) are coupled as evidenced by affinity CE-MS analysis

02 Jul 2008

publication

The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins

13 Jun 2008

publication

Small neutralizing molecules to inhibit actions of the chemokine CXCL12

24 Apr 2008

publication

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

19 Mar 2008

publication

Polypyrrole oligosaccharide array and surface plasmon resonance imaging for the measurement of glycosaminoglycan binding interactions

01 Mar 2008

publication

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling

14 Nov 2007

publication

An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain

31 Oct 2007

publication

The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4

01 Sep 2007

publication

Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO

15 Jul 2005

publication

Single-spanning membrane protein insertion in membrane mimetic systems: role and localization of aromatic residues

10 Apr 2005

publication

The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro

18 Feb 2005

publication

Synthesis of two linear PADRE conjugates bearing a deca- or pentadecasaccharide B epitope as potential synthetic vaccines against Shigella flexneri serotype 2a infection

15 Dec 2004

publication

CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytes

09 Nov 2004

publication

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

20 Sep 2004

publication

Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration

02 Aug 2004

publication

Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV

26 Apr 2004

publication

Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease

01 Apr 2004

publication

Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities

15 Mar 2003

publication

Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus

22 Nov 2002

publication

Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells

19 Nov 2002

publication

Deciphering the role of individual acyl chains in the interaction network between phosphatidylserines and a single-spanning membrane protein

01 Oct 2002

publication

Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant beta-sheet structure

26 Feb 2002

publication

Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4

15 Jan 2002

publication

Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant

21 Aug 2001

publication

Concerted influence of key amino acids on the lipid binding properties of a single-spanning membrane protein: NMR and mutational analysis

14 May 2001

publication

Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans

01 Feb 2001

publication

Production of stromal cell-derived factor 1 by mesothelial cells and effects of this chemokine on peritoneal B lymphocytes

21 Nov 2000

publication

Characterization of the stromal cell-derived factor-1alpha-heparin complex

01 Nov 2000

publication

Mimicking a conformational B cell epitope of the heat shock protein PfHsp70-1 antigen of Plasmodium falciparum using a multiple antigenic peptide

01 Sep 2000

publication

SDF-1-induced activation of ERK enhances HIV-1 expression

21 Aug 2000

publication

Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

01 Aug 2000

publication

Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes

01 Jan 2000

publication

Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes

01 Dec 1999

publication

Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein

20 Aug 1999

publication

Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine

01 Jul 1998

publication

A conformational equilibrium in a protein fragment caused by two consecutive capping boxes: 1H-, 13C-NMR, and mutational analysis

26 Jun 1998

publication

Exploring the folding pathways of annexin I, a multidomain protein. I. non-native structures stabilize the partially folded state of the isolated domain 2 of annexin I

17 Apr 1998

publication

Genomic organization and promoter characterization of human CXCR4 gene

01 Mar 1998

publication

Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation

01 Feb 1998

publication

Does a peptide bound to a monoclonal antibody always adopt a unique conformation?

01 Jan 1998

publication

Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype

26 Nov 1996

publication

NMR conformational study of the cytoplasmic domain of the canine Sec61 gamma protein from the protein translocation pore of the endoplasmic reticulum membrane

13 Aug 1996

publication

Folding properties of an annexin I domain: a 1H-15N NMR and CD study

01 Jun 1996

publication

Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo

01 May 1996

publication

Permanent occupancy of the human immunodeficiency virus type 1 enhancer by NF-kappa B is needed for persistent viral replication in monocytes

29 Mar 1996

publication

Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

01 Oct 1995

publication

Nonnative capping structure initiates helix folding in an annexin I fragment. A 1H NMR conformational study

01 Oct 1995

publication

Chemical structure and translation inhibition studies of the antibiotic microcin C7

29 Apr 1995

publication

Nascent chains: folding and chaperone interaction during elongation on ribosomes

01 Mar 1995

publication

Importance of residues 2-9 in the immunoreactivity, subunit interactions, and activity of the beta 2 subunit of Escherichia coli tryptophan synthase

20 Jul 1993

publication

Proton NMR conformational study of an annexin I fragment: influence of a phospholipidic micellar environment

01 Jul 1992

publication

Novel version of Multiple Antigenic Peptide allowing incorporation on a cysteine functionalized lysine tree

10 Mar 1992

publication

Peptide secondary structure induced by a micellar phospholipidic interface: proton NMR conformational study of a lipopeptide

01 Feb 1992

publication

1H-NMR conformational study of a synthetic peptide derived from the consensus sequence of annexins

01 Nov 1991

publication

1H-NMR conformational analysis of a high-affinity antigenic 11-residue peptide from the tryptophan synthase beta 2 subunit

01 Apr 1991

publication

Peptide/antibody recognition: synthetic peptides derived from the E. coli tryptophan synthase beta 2 subunit interact with high affinity with an anti-beta 2 monoclonal antibody

01 Dec 1989

publication

Reaction of staphylococcal alpha-toxin with peptide-induced antibodies

01 Oct 1989

publication

A new cell surface molecule closely related to mouse class I transplantation antigens

01 May 1977

publication

A little guide for advanced search:

Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri

Heparan sulfate differentially controls CXCL12α- and CXCL12γ-mediated cell migration through differential presentation to their receptor CXCR4

CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge

Well-defined biomimetic surfaces to characterize glycosaminoglycan-mediated interactions on the molecular, supramolecular and cellular levels

Mucin-like peptides from Echinococcus granulosus induce antitumor activity

Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12/proteoglycan interactions

CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension

Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain

A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti- HIV-1 activity independently of coreceptor usage

Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

Slightly modifying pseudoproline dipeptides incorporation strategy enables solid phase synthesis of a 54 AA fragment of caveolin-1 encompassing the intramembrane domain

A synthetic CD4-heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry

Glycosaminoglycan mimetics inhibit SDF-1/CXCL12-mediated migration and invasion of human hepatoma cells

Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (SDF-1/CXCL 12) are coupled as evidenced by affinity CE-MS analysis

The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins

Small neutralizing molecules to inhibit actions of the chemokine CXCL12

CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

Polypyrrole oligosaccharide array and surface plasmon resonance imaging for the measurement of glycosaminoglycan binding interactions

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling

An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain

The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4

Inhibition of NF-kappaB activation with designed ankyrin-repeat proteins targeting the ubiquitin-binding/oligomerization domain of NEMO

Single-spanning membrane protein insertion in membrane mimetic systems: role and localization of aromatic residues

The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro

Synthesis of two linear PADRE conjugates bearing a deca- or pentadecasaccharide B epitope as potential synthetic vaccines against Shigella flexneri serotype 2a infection

CXCR4-tropic HIV-1 envelope glycoprotein functions as a viral chemokine in unstimulated primary CD4+ T lymphocytes

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12

Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration

Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV

Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease

Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities

Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus

Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells

Deciphering the role of individual acyl chains in the interaction network between phosphatidylserines and a single-spanning membrane protein

Most of the structural elements of the globular domain of murine prion protein form fibrils with predominant beta-sheet structure

Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4

Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant

Concerted influence of key amino acids on the lipid binding properties of a single-spanning membrane protein: NMR and mutational analysis

Optimal inhibition of X4 HIV isolates by the CXC chemokine stromal cell-derived factor 1 alpha requires interaction with cell surface heparan sulfate proteoglycans

Production of stromal cell-derived factor 1 by mesothelial cells and effects of this chemokine on peritoneal B lymphocytes

Characterization of the stromal cell-derived factor-1alpha-heparin complex

Mimicking a conformational B cell epitope of the heat shock protein PfHsp70-1 antigen of Plasmodium falciparum using a multiple antigenic peptide

SDF-1-induced activation of ERK enhances HIV-1 expression

Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions

Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes

Differential signalling of the chemokine receptor CXCR4 by stromal cell-derived factor 1 and the HIV glycoprotein in rat neurons and astrocytes

Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein

Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine

A conformational equilibrium in a protein fragment caused by two consecutive capping boxes: 1H-, 13C-NMR, and mutational analysis

Exploring the folding pathways of annexin I, a multidomain protein. I. non-native structures stabilize the partially folded state of the isolated domain 2 of annexin I

Genomic organization and promoter characterization of human CXCR4 gene

Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation

Does a peptide bound to a monoclonal antibody always adopt a unique conformation?

Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype

NMR conformational study of the cytoplasmic domain of the canine Sec61 gamma protein from the protein translocation pore of the endoplasmic reticulum membrane

Folding properties of an annexin I domain: a 1H-15N NMR and CD study

Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo

Permanent occupancy of the human immunodeficiency virus type 1 enhancer by NF-kappa B is needed for persistent viral replication in monocytes

Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo

Nonnative capping structure initiates helix folding in an annexin I fragment. A 1H NMR conformational study

Chemical structure and translation inhibition studies of the antibiotic microcin C7

Nascent chains: folding and chaperone interaction during elongation on ribosomes

Importance of residues 2-9 in the immunoreactivity, subunit interactions, and activity of the beta 2 subunit of Escherichia coli tryptophan synthase

Proton NMR conformational study of an annexin I fragment: influence of a phospholipidic micellar environment

Novel version of Multiple Antigenic Peptide allowing incorporation on a cysteine functionalized lysine tree

Peptide secondary structure induced by a micellar phospholipidic interface: proton NMR conformational study of a lipopeptide

1H-NMR conformational study of a synthetic peptide derived from the consensus sequence of annexins

1H-NMR conformational analysis of a high-affinity antigenic 11-residue peptide from the tryptophan synthase beta 2 subunit

Peptide/antibody recognition: synthetic peptides derived from the E. coli tryptophan synthase beta 2 subunit interact with high affinity with an anti-beta 2 monoclonal antibody

Reaction of staphylococcal alpha-toxin with peptide-induced antibodies

A new cell surface molecule closely related to mouse class I transplantation antigens

[Injuries and diseases of the diaphragm]