Timeline

Antonio Freitas
Retired scientist
07 Sep 2015
project

ERC-2009-AdG QSIS

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13 Oct 2014
publication

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells

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27 Jun 2014
publication

Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice

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31 Dec 2013
publication

A mathematical perspective on CD4(+) T cell quorum-sensing

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18 Nov 2013
publication

IL-2 coordinates IL-2-producing and regulatory T cell interplay

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05 Aug 2013
publication

Origin, trafficking, and intraepithelial fate of gut-tropic T cells

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14 Jul 2013
publication

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells

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03 Dec 2012
publication

Quorum sensing contributes to activated IgM-secreting B cell homeostasis

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25 May 2012
publication

Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model

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09 Apr 2012
publication

Humanized mice: current states and perspectives

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14 Mar 2011
publication

Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools

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29 Apr 2010
publication

Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection

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16 Apr 2010
publication

CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism

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01 May 2009
publication

The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool

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01 Feb 2009
publication

Homeostasis of naive T cells: the Foxo that fixes

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31 Oct 2008
publication

Wild-derived mouse strains, a valuable model to study B cell responses

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01 Apr 2008
publication

TLR-activated B cells suppress T cell-mediated autoimmunity

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01 Jan 2008
publication

Peritoneal B-cell subsets in the genus Mus: their role in innate immunity

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15 Jun 2007
publication

Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6

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20 Sep 2006
publication

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells

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01 Jul 2006
publication

Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells

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12 Jun 2006
publication

The clone size of peripheral CD8 T cells is regulated by TCR promiscuity

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01 Dec 2005
publication

CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.

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21 Oct 2005
publication

IPEX and FOXP3: clinical and research perspectives

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17 Oct 2005
publication

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner

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18 Jul 2005
publication

Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation

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01 Jun 2005
publication

Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells

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01 Mar 2005
publication

In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects

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01 Feb 2005
publication

Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferation

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27 May 2004
publication

Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation

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15 Mar 2004
publication

Positive selection of B cells expressing low densities of self-reactive BCRs

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01 Feb 2004
publication

B-cell homeostasis, competition, resources, and positive selection by self-antigens

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01 Nov 2002
publication

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

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01 Apr 2002
publication

Introduction: regulation of lymphocyte homeostasis

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01 Dec 2001
publication

CD8+ T lymphocytes in double alpha beta TCR transgenic mice. II. Competitive fitness of dual alpha beta TCR CD8+ T lymphocytes in the peripheral pools

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01 Dec 2001
publication

CD8+ T lymphocytes in double alpha beta TCR transgenic mice. I. TCR expression and thymus selection in the absence or in the presence of self-antigen

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01 Oct 2001
publication

Resource competition determines selection of B cell repertoires

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01 Sep 2001
publication

T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors

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01 Feb 2001
publication

Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice

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01 Aug 2000
publication

Peripheral B cell survival

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01 Aug 2000
publication

B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pools

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01 Jan 2000
publication

Considerations on B cell homeostasis

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01 Jan 2000
publication

Population biology of lymphocytes: the flight for survival

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01 Apr 1999
publication

Peripheral T cell survival

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18 Jan 1999
publication

Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population

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01 Sep 1998
publication

The role of the B cell receptor V region in peripheral B cell survival

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01 Dec 1997
publication

Lymphocyte homeostasis

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26 Sep 1997
publication

Lymphocyte survival: a red queen hypothesis

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01 Jul 1997
publication

Independent homeostatic regulation of B cell compartments

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27 Jun 1997
publication

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

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27 May 1997
publication

Resource competition as a mechanism for B cell homeostasis

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01 Nov 1996
publication

Cellular competition modulates survival and selection of CD8+ T cells

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01 Jun 1996
publication

Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes

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01 Nov 1995
publication

Persistence of V beta 6+ T cells in Mls-1a mice. A role for the third complementarity-determining region (CDR3) of the T cell receptor beta chain in superantigen recognition

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01 Jun 1995
publication

The role of cellular competition in B cell survival and selection of B cell repertoires

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01 May 1995
publication

Lymphocytes in a model ecosystem

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01 Mar 1995
publication

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance

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01 Jun 1994
publication

Observations on the mode of action of normal immunoglobulin at high doses

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01 Jun 1994
publication

Regulation of VH-gene expression is a lineage-specific developmental marker

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01 Feb 1994
publication

Positive and negative selection of antibody repertoires during B-cell differentiation

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01 Feb 1994
publication

VH-gene family dominance in ageing mice

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01 Jun 1993
publication

V region dependent selection of persistent resting peripheral B cells in normal mice

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01 May 1993
publication

The physiology of bcl-2 expression in murine B lymphocytes

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01 Jan 1993
publication

Analysis of VH gene utilisation in the non-obese diabetic mouse

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01 Jan 1993
publication

Lymphocyte lifespans: homeostasis, selection and competition

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01 Oct 1992
publication

On the origin of natural IgM in immunoglobulin transgenic mice

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01 Jun 1992
publication

Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice

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01 Jan 1992
publication

Expression and selection of murine antibody repertoires

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01 Dec 1991
publication

Clonal analysis of B lymphocyte responses to Plasmodium chabaudi infection of normal and immunoprotected mice

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01 Sep 1991
publication

Clonal persistence of B lymphocytes in normal mice is determined by variable region-dependent selection

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01 Jul 1991
publication

Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires

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01 May 1991
publication

Normal serum immunoglobulins influence the numbers of bone marrow pre-B and B cells

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01 Jan 1991
publication

Endogenous VH gene family expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires

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01 Nov 1990
publication

Transfer of T or CD8+ cells from hemorrhaged mice produce alterations in bacterial antigen specific plasma cell repertoires in normal syngeneic recipients

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01 Oct 1990
publication

Selection of anti-F protein B-cell repertoires in normal mice

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01 Sep 1990
publication

Immunoglobulin VH gene expression following hemorrhage

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01 Aug 1990
publication

Accumulation of bromodeoxyuridine-labeled cells in central and peripheral lymphoid organs: minimal estimates of production and turnover rates of mature lymphocytes

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01 May 1990
publication

VH gene family repertoires of “viable motheaten” (mev) mice

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15 Mar 1990
publication

Purification and characterization of intraparenchymal lung lymphocytes

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01 Jan 1990
publication

Population kinetics of peritoneal LPS-reactive B lymphocytes

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01 Jan 1990
publication

Selection of VH gene repertoires: differentiating B cells of adult bone marrow mimic fetal development

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01 Aug 1989
publication

Hemorrhage in mice produces alterations in B cell repertoires

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01 Jun 1989
publication

Immunoglobulin VH gene expression in Ly-1+ and conventional B lymphocytes

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01 Jun 1989
publication

Interleukin 2 receptor expression and interleukin 2 production in exponentially growing T cells: major differences between in vivo and in vitro proliferating T lymphocytes

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01 Mar 1989
publication

Expression of VH11-gene family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity

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01 Feb 1989
publication

Hemorrhage produces abnormalities in lymphocyte function and lymphokine generation

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01 Jan 1989
publication

Selection of lymphocyte repertoires: the limits of clonal versus network organization

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01 Jan 1989
publication

Selection of antibody repertories: transfer of mature T lymphocytes modifies VH gene family usage in the actual and available B cell repertories of athymic mice

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01 Jan 1989
publication

Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment

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01 Jan 1989
publication

Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment

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15 Dec 1988
publication

Effects of surgical stress on lymphoid populations of mice

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01 Dec 1988
publication

Comparative study of VH gene family usage by newborn xid and non-xid mice, newborn NZB and adult NZB mice, and by splenic and peritoneal cavity B cell compartments

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01 Sep 1988
publication

Secondary antibody responses to thymus-independent antigens. Decline and life-span of memory

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01 Sep 1988
publication

Long-lasting thymus-independent immune responses to anti-idiotype lipopolysaccharide conjugates require continuous B cell renewal

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15 Jun 1988
publication

Selection of antibody repertoires by anti-idiotypes can occur at multiple steps of B cell differentiation

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01 Jun 1987
publication

The majority of “natural” immunoglobulin-secreting cells are short-lived and the progeny of cycling lymphocytes

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01 May 1987
publication

Altered fatty acid membrane composition modifies lymphocyte localization in vivo

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01 Nov 1986
publication

Effects of hydroxyurea in vivo treatment on the antibody response in mice

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01 Oct 1986
publication

Antibody repertoires of normal BALB/c mice: B lymphocyte populations defined by state of activation

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01 Jul 1986
publication

Analysis of autoantibody reactivities in hybridoma collections derived from normal adult BALB/c mice

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01 Jul 1986
publication

Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice

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01 Mar 1986
publication

The effects of lymph on lymphocyte migration in vivo

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01 Jan 1986
publication

Two major classes of mitogen-reactive B lymphocytes defined by life span

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01 Jan 1986
publication

Life span of B lymphocytes: the experimental basis for conflicting results

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01 Nov 1984
publication

Lymphocytes migration into membrane filters: divergent effects of syngeneic mouse serum and lymph

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01 Apr 1984
publication

Effects of hydroxyurea on concanavalin-A-induced T-cell proliferation. Depletion of T-cell growth factor-reactive and -producing T lymphocytes

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01 Apr 1984
publication

Lymphocyte migration into collagen gels: role of lymph

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01 Nov 1983
publication

Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs

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01 Jul 1983
publication

From the mechanisms of lymphocyte activation to internal activity in the immune system

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01 May 1982
publication

Spleen lymphocyte populations in patients with Hodgkin’s disease–properties of cells with different densities

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01 Jan 1982
publication

Population dynamics of B lymphocytes and their precursors: demonstration of high turnover in the central and peripheral lymphoid organs

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01 Sep 1981
publication

Very rapid decay of mature B lymphocytes in the spleen

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01 Dec 1980
publication

Characterization of rat spleen cell populations. II. Activation by antigens and allogeneic cells

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01 Oct 1980
publication

Characterization of mouse thoracic duct B lymphocytes. I. Evidence of functional heterogeneity

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01 Apr 1979
publication

Characterization of rat spleen-cell populations. I. Cell interactions in the regulation of in vitro response to concanavalin A

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15 Feb 1979
publication

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase

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01 Feb 1979
publication

The role of locomotion in lymphocyte migration

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01 Oct 1978
publication

Effects of solute-coupled transport on lymph flow and oncotic pressures in cat ileum

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01 Jun 1978
publication

[Osteogenic sarcoma in an 8-year-old girl]

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01 Jan 1978
publication

Divergent actions of monomeric, dimeric, and tetrameric concanavalin A on lymphocyte traffic

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22 Dec 1977
publication

Murine mesenteric and peripheral lymph nodes: a common pool of small T cells

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01 Jun 1977
publication

Control mechanism of lymphocyte traffic. A study of the action of two sulfated polysaccharides on the distribution of 51Cr- and [3H]adenosine-labeled mouse lymph node cells

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01 Oct 1976
publication

Control mechanism of lymphocyte traffic. Altered migration of 51Cr-labeled mouse lymph node cells pretreated in vitro with phospholipases

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01 Apr 1976
publication

Control mechanism of lymphocyte traffic. Altered distribution of 51Cr-labeled mouse lymph node cells pretreated in vitro with lipopolysaccharide

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15 Mar 1976
publication

The role of cell interactions in the control of lymphocyte traffic

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01 Feb 1976
publication

Factors which determine the accumulation of immunoblasts in gut and skin

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01 Jan 1976
publication

Role of prostaglandins (PGs) in the control of adenohypophyseal hormone secretion

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