Timeline
Antonio Freitas
Retired scientist
07 Sep 2015
13 Oct 2014
publication
microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells
Read more27 Jun 2014
publication
Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice
Read more31 Dec 2013
18 Nov 2013
05 Aug 2013
14 Jul 2013
publication
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
Read more03 Dec 2012
25 May 2012
09 Apr 2012
14 Mar 2011
publication
Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8 T(CM) and T(EM) cell pools
Read more29 Apr 2010
publication
Endogenous TCR recombination in TCR Tg single RAG-deficient mice uncovered by robust in vivo T cell activation and selection
Read more16 Apr 2010
01 May 2009
publication
The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool
Read more01 Feb 2009
31 Oct 2008
01 Apr 2008
01 Jan 2008
15 Jun 2007
publication
Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6
Read more20 Sep 2006
publication
Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells
Read more01 Jul 2006
publication
Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells
Read more12 Jun 2006
01 Dec 2005
21 Oct 2005
17 Oct 2005
publication
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner
Read more18 Jul 2005
publication
Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation
Read more01 Jun 2005
publication
Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells
Read more01 Mar 2005
publication
In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects
Read more01 Feb 2005
publication
Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferation
Read more27 May 2004
publication
Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation
Read more15 Mar 2004
01 Feb 2004
publication
B-cell homeostasis, competition, resources, and positive selection by self-antigens
Read more01 Nov 2002
publication
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
Read more01 Apr 2002
01 Dec 2001
publication
CD8+ T lymphocytes in double alpha beta TCR transgenic mice. II. Competitive fitness of dual alpha beta TCR CD8+ T lymphocytes in the peripheral pools
Read more01 Dec 2001
publication
CD8+ T lymphocytes in double alpha beta TCR transgenic mice. I. TCR expression and thymus selection in the absence or in the presence of self-antigen
Read more01 Oct 2001
01 Sep 2001
publication
T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors
Read more01 Feb 2001
publication
Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice
Read more01 Aug 2000
01 Aug 2000
publication
B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pools
Read more01 Jan 2000
01 Jan 2000
01 Apr 1999
18 Jan 1999
publication
Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population
Read more01 Sep 1998
01 Dec 1997
26 Sep 1997
01 Jul 1997
27 Jun 1997
publication
Differential requirements for survival and proliferation of CD8 naïve or memory T cells
Read more27 May 1997
01 Nov 1996
01 Jun 1996
publication
Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes
Read more01 Nov 1995
publication
Persistence of V beta 6+ T cells in Mls-1a mice. A role for the third complementarity-determining region (CDR3) of the T cell receptor beta chain in superantigen recognition
Read more01 Jun 1995
publication
The role of cellular competition in B cell survival and selection of B cell repertoires
Read more01 May 1995
01 Mar 1995
publication
Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance
Read more01 Jun 1994
01 Jun 1994
01 Feb 1994
publication
Positive and negative selection of antibody repertoires during B-cell differentiation
Read more01 Feb 1994
01 Jun 1993
publication
V region dependent selection of persistent resting peripheral B cells in normal mice
Read more01 May 1993
01 Jan 1993
01 Jan 1993
01 Oct 1992
01 Jun 1992
publication
Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice
Read more01 Jan 1992
01 Dec 1991
publication
Clonal analysis of B lymphocyte responses to Plasmodium chabaudi infection of normal and immunoprotected mice
Read more01 Sep 1991
publication
Clonal persistence of B lymphocytes in normal mice is determined by variable region-dependent selection
Read more01 Jul 1991
publication
Normal serum immunoglobulins participate in the selection of peripheral B-cell repertoires
Read more01 May 1991
publication
Normal serum immunoglobulins influence the numbers of bone marrow pre-B and B cells
Read more01 Jan 1991
publication
Endogenous VH gene family expression in immunoglobulin-transgenic mice: evidence for selection of antibody repertoires
Read more01 Nov 1990
publication
Transfer of T or CD8+ cells from hemorrhaged mice produce alterations in bacterial antigen specific plasma cell repertoires in normal syngeneic recipients
Read more01 Oct 1990
01 Sep 1990
01 Aug 1990
publication
Accumulation of bromodeoxyuridine-labeled cells in central and peripheral lymphoid organs: minimal estimates of production and turnover rates of mature lymphocytes
Read more01 May 1990
15 Mar 1990
01 Jan 1990
01 Jan 1990
publication
Selection of VH gene repertoires: differentiating B cells of adult bone marrow mimic fetal development
Read more01 Aug 1989
01 Jun 1989
01 Jun 1989
publication
Interleukin 2 receptor expression and interleukin 2 production in exponentially growing T cells: major differences between in vivo and in vitro proliferating T lymphocytes
Read more01 Mar 1989
publication
Expression of VH11-gene family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity
Read more01 Feb 1989
publication
Hemorrhage produces abnormalities in lymphocyte function and lymphokine generation
Read more01 Jan 1989
publication
Selection of lymphocyte repertoires: the limits of clonal versus network organization
Read more01 Jan 1989
publication
Selection of antibody repertories: transfer of mature T lymphocytes modifies VH gene family usage in the actual and available B cell repertories of athymic mice
Read more01 Jan 1989
publication
Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment
Read more01 Jan 1989
publication
Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment
Read more15 Dec 1988
01 Dec 1988
publication
Comparative study of VH gene family usage by newborn xid and non-xid mice, newborn NZB and adult NZB mice, and by splenic and peritoneal cavity B cell compartments
Read more01 Sep 1988
publication
Secondary antibody responses to thymus-independent antigens. Decline and life-span of memory
Read more01 Sep 1988
publication
Long-lasting thymus-independent immune responses to anti-idiotype lipopolysaccharide conjugates require continuous B cell renewal
Read more15 Jun 1988
publication
Selection of antibody repertoires by anti-idiotypes can occur at multiple steps of B cell differentiation
Read more01 Jun 1987
publication
The majority of “natural” immunoglobulin-secreting cells are short-lived and the progeny of cycling lymphocytes
Read more01 May 1987
publication
Altered fatty acid membrane composition modifies lymphocyte localization in vivo
Read more01 Nov 1986
01 Oct 1986
publication
Antibody repertoires of normal BALB/c mice: B lymphocyte populations defined by state of activation
Read more01 Jul 1986
publication
Analysis of autoantibody reactivities in hybridoma collections derived from normal adult BALB/c mice
Read more01 Jul 1986
publication
Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice
Read more01 Mar 1986
01 Jan 1986
01 Jan 1986
01 Nov 1984
publication
Lymphocytes migration into membrane filters: divergent effects of syngeneic mouse serum and lymph
Read more01 Apr 1984
publication
Effects of hydroxyurea on concanavalin-A-induced T-cell proliferation. Depletion of T-cell growth factor-reactive and -producing T lymphocytes
Read more01 Apr 1984
01 Nov 1983
publication
Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs
Read more01 Jul 1983
publication
From the mechanisms of lymphocyte activation to internal activity in the immune system
Read more01 May 1982
publication
Spleen lymphocyte populations in patients with Hodgkin’s disease–properties of cells with different densities
Read more01 Jan 1982
publication
Population dynamics of B lymphocytes and their precursors: demonstration of high turnover in the central and peripheral lymphoid organs
Read more01 Sep 1981
01 Dec 1980
publication
Characterization of rat spleen cell populations. II. Activation by antigens and allogeneic cells
Read more01 Oct 1980
publication
Characterization of mouse thoracic duct B lymphocytes. I. Evidence of functional heterogeneity
Read more01 Apr 1979
publication
Characterization of rat spleen-cell populations. I. Cell interactions in the regulation of in vitro response to concanavalin A
Read more15 Feb 1979
publication
Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase
Read more01 Feb 1979
01 Oct 1978
publication
Effects of solute-coupled transport on lymph flow and oncotic pressures in cat ileum
Read more01 Jun 1978
01 Jan 1978
publication
Divergent actions of monomeric, dimeric, and tetrameric concanavalin A on lymphocyte traffic
Read more22 Dec 1977
01 Jun 1977
publication
Control mechanism of lymphocyte traffic. A study of the action of two sulfated polysaccharides on the distribution of 51Cr- and [3H]adenosine-labeled mouse lymph node cells
Read more01 Oct 1976
publication
Control mechanism of lymphocyte traffic. Altered migration of 51Cr-labeled mouse lymph node cells pretreated in vitro with phospholipases
Read more01 Apr 1976
publication
Control mechanism of lymphocyte traffic. Altered distribution of 51Cr-labeled mouse lymph node cells pretreated in vitro with lipopolysaccharide
Read more15 Mar 1976
01 Feb 1976
01 Jan 1976
publication