Timeline
Grazyna Faure-Kuzminska
Permanent Researcher
22 Dec 2022
publication
Design of crotoxin-based peptides with potentiator activity targeting the ΔF508NBD1 Cystic Fibrosis Transmembrane Conductance Regulator.
Read more13 Nov 2020
publication
Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets.
Read more13 Nov 2018
event
25th Meeting (RT25) of the French Society of Toxinology (SFET) : “Toxins and Health: from Molecules to Organisms”.
Read more28 Feb 2018
patent
Rattlesnake Phospholipase A2 increases CFTR-chloride channel current and corrects DF508CFTR dysfunction providing scaffold for chemical synthesis of dual modulators correctiong DF508CFTR ; application to treatment of Cystic Fibrosis
Read more30 Nov 2017
publication
Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors
Read more12 Oct 2017
publication
Pancreatic and snake venom presynaptically active phospholipases A2 inhibit nicotinic acetylcholine receptors
Read more14 Apr 2017
01 Feb 2017
publication
New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8
Read more15 Jul 2016
publication
Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models
Read more27 May 2016
publication
Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis
Read more05 Feb 2016
publication
Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)
Read more28 Jan 2016
21 Sep 2014
27 Aug 2013
publication
Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain
Read more07 Jun 2012
publication
Crystallographic characterization of functional sites of crotoxin and ammodytoxin, potent β-neurotoxins from Viperidae venom
Read more01 Dec 2011
publication
Structural and Functional Characterization of Anticoagulant, FXa-binding Viperidae Snake Venom Phospholipases A2
Read more28 Oct 2011
publication
Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect
Read more23 Jul 2011
publication
Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric β-neurotoxin
Read more24 May 2010
publication
Functional and immunological characterization of the var2CSA-DBL5epsilon domain of a placental Plasmodium falciparum isolate
Read more22 Oct 2009
publication
Eicosanoid release is increased by membrane destabilization and CFTR inhibition in Calu-3 cells
Read more06 Dec 2007
publication
Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics
Read more26 Oct 2007
publication
The first phospholipase inhibitor from the serum of Vipera ammodytes ammodytes
Read more16 Dec 2006
publication
Cross-reactivity studies of an anti-Plasmodium vivax apical membrane antigen 1 monoclonal antibody: binding and structural characterisation
Read more07 Nov 2006
publication
Receptor-binding studies of the DBLgamma domain of Plasmodium falciparum erythrocyte membrane protein 1 from a placental isolate
Read more17 Jan 2006
publication
Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity
Read more07 Jul 2005
publication
The C-terminal and beta-wing regions of ammodytoxin A, a neurotoxic phospholipase A2 from Vipera ammodytes ammodytes, are critical for binding to factor Xa and for anticoagulant effect
Read more10 Nov 2003
21 Mar 2003
publication
The neurotoxic phospholipase A2 associates, through a non-phosphorylated binding motif, with 14-3-3 protein gamma and epsilon isoforms
Read more01 Mar 2003
publication
Crotoxin acceptor protein isolated from Torpedo electric organ: binding properties to crotoxin by surface plasmon resonance
Read more06 Feb 2003
publication
Actin dynamics is controlled by a casein kinase II and phosphatase 2C interplay on Toxoplasma gondii Toxofilin
Read more15 Feb 2002
publication