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© Research
Publication : Proteins

A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study

Team: Group: Biochemistry and chemobiology
Team: Archived: Group : Chemistry and Biocatalysis
Member: Hélène Munier-Lehmann
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proteins - 01 Aug 1999

Munier-Lehmann H, Burlacu-Miron S, Craescu CT, Mantsch HH, Schultz CP

Link to Pubmed [PMID] – 10398370

Proteins 1999 Aug;36(2):238-48

The adk gene from Mycobacterium tuberculosis codes for an enzyme of 181 amino acids. A sequence comparison with 52 different forms of adenylate kinases (AK) suggests that the enzyme from M. tuberculosis belongs to a new subfamily of “short” bacterial AKs. The recombinant protein, overexpressed in Escherichia coli, exhibits a low catalytic activity and an unexpectedly high thermal stability (Tm = 64.8 degrees C). Based on various spectroscopic data, on the known three-dimensional structure of the AK from E. coli and on secondary structure predictions for various sequenced AKs, we propose a structural model for AK from M. tuberculosis (AKmt). Proteins 1999;36:238-248.